![]() ![]() In the example of NCC, should we use serological markers or CT scan findings as evidence of NCC? Such a question raises further questions. ![]() ![]() Further considerations in clinical research, such as the clinical setting, study design, selection criteria, data collection and analysis, are influenced by the disease characteristics, prevalence, time availability, expertise, research grants and several other factors. Once we have a fairly well-defined research question, we need to consider the best strategy to address these questions. In this paper, we focus attention on residents and younger faculty who are planning short-term research projects that could be completed in 2–3 years. For example, do persons with epilepsy have a higher probability of having serological (or computed tomography scan) markers for NCC? What proportion of persons with multiple lesions in the brain has Multiple Sclerosis (MS) Do children with pyogenic meningitis have a lesser risk of mortality if dexamethasone is used concomitantly with antibiotics?ĭesigning a clinical study involves narrowing a topic of interest into a single focused research question, with particular attention paid to the methods used to answer the research question from a cost, viability and overall effectiveness standpoint. Is there an association between neurocysticercosis (NCC) and epilepsy? Are magnetic resonance imaging changes good predictors of multiple sclerosis? Is there a benefit in using steroids in pyogenic meningitis? Typically, these questions lead us to set up more refined research questions. Clinical research often starts from questions raised at the bedside in hospital wards. ![]()
0 Comments
Leave a Reply. |